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    Designing therapeutics with
    engineering precision

    "It is more important to know what sort of person has a
    disease than to know what sort of disease a person has."
    Hippocrates (~380 BC)

PRECISION MEDICINE

 

why precision medicine?

No two patients are alike. Recent medical science discoveries show tremendous differences in genomic abnormalities among individual patients with the same disease. These breakthrough findings of genetic heterogeneity and subclonal disease architecture explain why individual patient responses to one-size-fits-all treatment are variable and transient.

The goal of precision medicine is to tailor treatment to the individual patient using the patient’s distinctive disease information. By using patient-specific molecular data, precision medicine empowers health care providers with a more educated understanding of the patient and enables rational design of treatment plans with the best possibility for success.

what is the need?

The medical community now recognizes the potential of precision medicine to transform health care.While physicians are increasingly ordering molecular tests on their patients, less than 1% of the test results are actually used in patient management due to the complexity and large amount of information.


Every health evaluation and medical decision depends upon the quality and thoroughness of examination results. When it comes to managing patients in the post-genomic era, health care providers need help in interpreting the complicated and immense quantity of test results so that the patient-specific information can be used to its fullest potential.



our approach

Advances in laboratory technology have lowered the cost and turn-around time of generating large genomic and proteomic datasets from patients. Until recently, it was not possible to clinically interpret these molecular data with respect to the individual. Today we can.

Cellworks uses a specialized technology to create simulation models of diseases like Cancer. Using genomic data of the patient, Cellworks creates a computer-simulated avatar and then uses the personalized avatar to design and test possible therapies. Cellworks precision medicine results are the most detailed insight into the individual patient's disease and potential treatments available anywhere.

Cellworks empowers physicians to fully understand the significance of complex genomic mutations in every patient. With greater understanding comes greater power to heal. This, truly, is personalized therapy.

benefits

Our precision medicine platform simulates millions of experiments for a specific patient on a HIPAA-compliant Cloud infrastructure, and helps payers and providers improve quality of care while reducing cost.

Physicians at point of care can make better-informed decisions customized for each patient and potentially identify treatment options where none existed before. With Cellworks, life science companies can develop and test products for the right audience.

Contact us to learn how Cellworks combines the latest advances in genomics with power of the Cloud computing today to give simulated predictions for individual patients.

TEAM

 

  • Management
  • Board of Directors
  • 585-519-0982Clinical Advisory Board
       
Taher Abbasi Taher Abbasi
Shireen Vali Shireen Vali
Marc Shuman Marc Shuman
Taher Abbasi Taher Abbasi
Bill Rutter Bill Rutter
Yatin Mundkur Yatin Mundkur
David M. Lawrence David M. Lawrence
Mike Goguen Mike Goguen
Chi Van Dang Chi Van Dang
Daphne A. Haas-Kogan Daphne A. Haas-Kogan
John F. DiPersio John F. DiPersio
Eric Small
Eric Small

SOLUTIONS

 

Cellworks offers highly innovative precision medicine solutions to create patient-specific actionable insights using the patient’s existing genomics and proteomics reports. While cancer profiling like gene sequencing provide cancer mutation information, interpreting these results is challenging due to the large volume and complexity of the data. Cellworks holistically integrates patient-specific genomic and proteomic test results to create actionable insights so that the treating physician has a full understanding of the patient’s disease. With Cellworks assistance, physicians are empowered to take full advantage of molecular testing and rationally design personalized treatments with greatest chance for success.


FEATURES PRODUCT
Free Premium

Input Formats
NGS - Targeted gene Panel(FoundationOne) Additional Formats
ACGH (Agilent Microarray / MoGene, GenPath)
NGS - Targeted Gene Panel (NeoGenomics)

Simulated Drug Agents Library
FDA Approved agents Additional Phase 3 Clinical Trial Agents

Customized Personalization
Reduction of Cancer Growth or Proliferation or Viability Additional Custom Personalization

Facts

 

50+

Global Collaborators

125+

Team Members

1000+

Validations

Yes

HIPAA Compliant

Yes

Secure

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FAQ

 

1. What molecular testing is currently supported?

Array comparative genomic hybridization ( Agilent Microarray (MoGene) - probe based hybridization, GenPath : array CGH ), NGS - Targeted gene panel ( NeoGenomics - Targeted gene panel, FoundationOne ), Targeted Nucleotide Sequencing ( OneSeq, Farsight ), RNA ( Illumina ), Proteomics ( iTraq ), AVCF ( DNA Rails )

2. What is the Cellworks ACT Score?

The Cellworks ACT score indicates the level of confidence associated with the predicted therapy. This is determined by the comprehensiveness, quality of data input, and coverage of the perturbed genes in the predictive technology. The ACT score is a number between 1 to 5, with higher scores indicating a high confidence in the predicted personalized therapy.

3. What cancer types does Cellworks modeling not support?

Currently we do not model sarcomas and hormone driven cancers.

4. I have a Foundation One report. Can this be used for modeling?

Yes. We can use the reported gene mutations whether actionable by a drug target or not. In addition to the Foundation One report, chromosome copy number variation, as measured by array CGH, helps improve precision analysis. Please contact us to discuss how to add array CGH testing.

5. How can I use the Cellworks simulation analysis output?

The simulation modeling highlights key dysregulated pathways and predicts novel drug combinations with therapeutic potential specific for the patient. Cellworks reports empower treating physicians with greater understanding of their patients’ cancer. With greater understanding, physicians can make better data-driven decisions in evaluating and managing their patients.

6. Can Cellworks simulation predict up front whether the approved drug agent for the target indication will be effective?

It depends on many factors like mechanism of action of drug, lack of response due to immune cytokine environment or patient genomics. Cellworks simulation does not model chemotherapy drug agents or cytotoxic drug agents which lack a specific mechanism of action.

CONTACT US

 

Mailing Address

Cellworks Group Inc.(Corporate Office)
2033 Gateway Place, Suite 500, San Jose, California - 95110
+1 408 467 3805
Email: precisionmedicine@cellworksgroup.com
cellworksgroup.com

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